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KMID : 0363320100310030600
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Journal of Korean Oriental Internal Medicine
2010 Volume.31 No. 3 p.600 ~ p.611
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Nephroprotective Effects of Opi-san Aqueous Extracts on Cisplatin-induced Rat Acute Renal Failure
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Kim Tae-Woo
Yoon Keong-Min
Im Eun-Young
Shin Hyeon-Cheol
Kang Suk-Bong
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Abstract
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Purpose:This study was to observe the nephroprotective effects of the traditional prescription, Opi-san(OPS). OPS has been generally used for treating various edematous renal diseases, including acute renal failure.
Methods:Three different dosages of OPS extracts were administered once a day for 28 days (5 mg/kg, single intraperitoneally administered). On the 23rd day after OPS extract treatment, cisplatin was treated. All the rats (6 groups of 8 rats each) were checked as follows. Changes of body weight, kidney weight, serum BUN and creatinine levels were observed, as well as changes to the kidney MDA and GSH contents. The results were compared with captopril 100 mg/kg, of which the effects on cisplatin-induced acute renal failures were already confirmed.
Results:Cisplatin-induced ARF were induced by oxidative stress and related lipid peroxidation in the present study. However, these ARF and inhibition of antioxidant effects induced by cisplatin were dose-dependently reduced by treatment of OPS extracts except in the 100 mg/kg treated group. The effects of OPS extracts at 500 mg/kg were similar to those of 100 mg/kg of captopril.
Conclusion:This study suggests that OPS extracts 500 mg/kg showed favorable effects on the cisplatin-induced rat’s ARF as similar to 100 mg/kg of captopril.
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KEYWORD
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Opi-san(Wupi-san), ARF, Cisplatin, Antioxidant effect
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